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Between October 1998 and September 2000 10 patients were investigated for macroprolactinaemia in an endocrinological consultancy. Patient data are shown in Table 1. The main reason for the work-up was the discrepancy between elevated prolactin value on the one hand and the clinical findings on the other. Despite significant hyperprolactinaemia, galactorrhoea and persistent amenorrhoea were present in only two cases, erectile function and sexual life were unaffected, pituitary MRI failed to show pituitary masses with the sole exception of pat. 6, in whom a prolactinoma was found at operation. Although in pat. 1 MRI prompted suspicion of an in. Subsequent to the 1998 2nd Scientific Symposium on CVS, CVSA awarded Dr. Boles a $10, 000 pilot grant to begin his study. He is now working on CVS3, the third section of this work. Starting in early June, randomly selected members of CVSA were contacted for possible participation in this study. The selection was done by the last 2 digits of the zip code. If you were contacted, please respond promptly to learn more about the study. There is no travel involved. In the current CVS3 study, the full mitochondrial DNA will be sequenced the genetic code read ; looking for any sequence differences, including mutations. There will also be studies of mitochondrial function, such as how energy is produced in the subjects' mitochondria, performed in cell cultures grown from the subjects' blood samples. Hair samples will be obtained from the subjects' mothers and fathers in order to compare DNA sequences genetic code ; between the subjects and their parents. The CVS3 study will take between three and five years to complete. The goal of CVS3 is to understand the way that maternally-inherited mtDNA sequence variants contribute to the occurrence of CVS. In addition, Dr. Boles hopes to learn how those same changes, or mutations, in the mtDNA genetic code contribute towards the development of certain conditions in the maternal line, including migraine headaches, depression, irritable bowel, and chronic fatigue. It is hoped that this knowledge would be useful in the clinical management of these conditions, as it has shown to be the case in finding new therapies for children with CVS. NOTE: The full article about Dr. Boles' work is available in the February 2006 issue of the Code V email Debra Waites for a copy at waitesd cvsaonline. Triptan drugs are effective in 60% to 65% of patients, completely or significantly relieving migraine pain and associated symptoms within 2 hours of administration.

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