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Moderately severe to severe Alzheimer's disease. Ebixa is expected to fulfil unmet needs within this group of patients for whom no approved treatment has been available until now. Data on Ebixa presented at the Alzheimer's Association 8th International Conference on Alzheimer's Disease and Related Disorders held in Stockholm from 20-25 July demonstrated several potential benefits. Ebixa showed clinical efficacy over a period of one year, reduced the need for care and reduced costs to society, is well-tolerated in patients receiving combined therapy with cholinesterase inhibitors, and showed a protective effect on brain cells in preclinical studies. Ebixa has already been marketed in Germany and Denmark, and the drug will be introduced into the other European markets from the second half of 2002. In addition, Ebixa has been approved in Mexico where it has already been marketed.
This alert highlights some of the key health care conclusions and their implications for practice as published this week in The Cochrane Library, 2006, Issue 2. To receive a full copy of the reviews highlighted in this newsletter, or to arrange an interview with an author, contact Polly Young + 44 0 ; 1243 770633 or by email pyoung wiley ; . Reviews highlighted in this newsletter: Insecticide treated nets beneficial for pregnant women in malariaendemic Africa Insecticide treated nets ITNs ; reduces placental malaria, low birth weight and abortions and stillbirths in women living in malaria affected regions of Africa. The benefit is most noticeable in women during their first two to four pregnancies. The effect is seen if the ITNs are used by communities or by individual women. Directly Observed Therapy does not help fight Tuberculosis Directly observed therapy DOT ; has no quantitatively important effect on cure rates or treatment completion in people receiving treatment for tuberculosis TB ; . So concludes a systematic review of randomized controlled trials conducted in low-, middle, and high-income countries and effexor.
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The program introduces you to a number of experts in the field. Because Sexual Medicine is multidisciplinary, physicians and other health care professionals expressed the need for a comprehensive review of the common problems seen in this field. We trust this program will provide you with answers to your many questions and that you will leave informed of current issues and their management. We hope that you gain knowledge of sexual medicine that can be incorporated into your clinical practice and elocon, for instance, diovan blood pressure medication.
DIOVAN HCT valsartan hydrochlorothiazide ; . DIOVAN valsartan ; . DIPROLENE betamethasone dipropionate 0.05% ; DISALCID salsalate ; . DITROPAN oxybutinin ; . DIURIL chlorothiazide ; . DOLOPHINE methadone ; . DOMEBORO OTIC acetic acid aluminum acetate.
The patient was able to leave home and shop for the first time in three years, and also became more compliant with taking medications, and improved compliance with scheduled office visits. It was felt that IM B No would further improve the patient's condition but she would not tolerate the injections. The patient remains stable on Samento and anti-hypertension Diiovan ; medication alone. CASE #5 PK, 56-year-old white female, who since 1998 has suffered neuralgia-like pain and burning sensations in the oral mucosa. Also night sweats, chronic muscle and joint pain, fatigue, short-term memory loss, and visual blurring "seems my eyeglasses are dirty when they are clean." ; Occult dental infection was corrected with oral surgery and a combination of oral penicillin and clindamycin. Symptomatic relief lasted several weeks after which the dental oral facial neuralgia returned. The patient subsequently was diagnosed with Lyme's disease by fluorescing antibody. Colloidal silver MSP ; was initiated along with homeopathic Ledum, resulting in partial relief of symptoms. SAMENTO was added to the above regimen and increased the patient's symptomatic relief to approximately 95%. CASE #6 FC, 75 year old white male, with a long history of chronic fatigue syndrome and fibromyalgia, and depression. Chronic worsening symptoms of fatigue, muscle soreness, and cognitive loss "I just can't think clearly" ; had rendered the patient almost housebound. Domestic support is minimal as the patient is married to a sedentary chain smoker little interested in her own health problems and who ridicules the patient's search for health in the alternative medical field. The patient also suffers from insomnia, which could more rightly be described as a loss of circadian rhythm as the patient is unable to fall asleep at night, then chronically is unable to awaken in the mornings. The patient takes Xanax, cytomel, Allegra, Humulin R and N. Treatment with Nutri-Spec diphasic supplementation designed to help restore a more normal diurnal rhythm met with limited success. The addition of SAMENTO resulted in a marked improvement in the patient's energy level, sense and evista.
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Steven Aks, DO, John H. Stroger, Jr. Hospital of Cook County Jack Clifton, MD, John H. Stroger, Jr. Hospital of Cook County Timothy Erickson, MD, University of Illinois Medical Center at Chicago Michele Kanter, PharmD, John H. Stroger, Jr. Hospital of Cook County Anne Krantz, MD, John H. Stroger, Jr. Hospital of Cook County Jerrold Leikin, MD, Evanston Northwestern Healthcare Mark Mycyk, MD, Northwestern Memorial Hospital Frank Paloucek, PharmD, University of Illinois Medical Center at Chicago and flomax.
Symptoms are indicative of a disease has led to a situation in which only some of these women are receiving appropriate treatment. Takeda's subsidiary Takeda Pharma GmbH in Germany, which is selling leuprolide acetate as Enantone, the treatment for prostate cancer and endometriosis, is trying to address this problem by providing opportunities mainly for young gynecologists to learn about endometriosis diagnosis and new treatment methods. The company is also supplying patient education materials to help physicians explain the condition to their patients.
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As social and economic conditions drastically change, Asian countries face challenges to establish systems for fairly and effectively resolving the variety of disputes that arise increasingly in our societies. For dispute resolution, litigation in the court is not the only option. Mediation and arbitration proceedings outside the courts are important facilities as well. In addition, administrative organs and private organizations such as bar associations function as resolution systems for dealing with the increasing number of disputes. While discussions on out-of-court dispute, for example, generic for diovan hct.
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EEA1, interacts not only with an effector of Vps21 a yeast Rab protein ; , but also with Vps45, a member of the Sec1 Munc18 family 569 ; . In addition, other docking complexes regulated by Rab proteins have been characterized. For example, Rabphilin-3 and Rim, two effectors of Rab3 proteins, may be part of a complex that links synaptic vesicles to the presynaptic plasma membrane in neurons. G. Rab3A in Ca2 -Dependent Exocytosis Transient overexpression or microinjection of a dominant active mutant of Rab3A inhibits Ca2 -dependent secretion from bovine chromaffin cells and PC12 cells as described above 282, 319 ; . In contrast, Rab3B stimulates secretion: in antisense RNA experiments performed in anterior pituitary cells, reduction in Rab3B mRNA inhibited Ca2 -dependent secretion from these cells 407 ; , and when a dominant active mutant of Rab3B was stably expressed in PC12 cells, where endogenous Rab3B is absent, Ca2 -dependent norepinephrine secretion was markedly stimulated 772 ; . The explanation for these apparently opposite effects of Rab3A and Rab3B on Ca2 dependent exocytosis is currently unknown. Studies on Rab3A-deficient mice have revealed an important insight into Rab3A function. Synaptic depletion is much faster in the hippocampal CA1 region of these mice, although two forms of short-term synaptic plasticity, paired-pulse facilitation and posttetanic potentiation, are unaffected 216 ; . These findings suggest that Rab3A plays a role in the recruitment of synaptic vesicles for exocytosis. In Rab3A-deficient, cultured hippocampal cells, Rab3A is involved in a late step in vesicle fusion 217 ; . Moreover, Rab3A-deficient mice show reduced formation of postsynaptic long-term potentiation in the CA3 region 91 ; . Thus Rab3A is not essential for basal synaptic transmission; rather, it modulates synaptic vesicle trafficking, thereby contributing to synaptic plasticity. Recent genetic analysis of X-linked, nonspecific, mental retardation has revealed that mutations or deletions of the Rab GDI gene can cause this disease 138 ; . Notably, Rab GDI is localized to the distal part of chromosome Xq28. Mutations in this region have recently been described to cause a syndromic form of X-linked nonspecific mental retardation that comprises epileptic seizures 29 ; . Consistent with these findings, analysis of Rab GDI -deficient mice has shown that synaptic potentials remain elevated and show reduced depression during repetitive stimulation in the hippocampal CA1 region 306 ; . In addition, the mice have increased propensity for seizures. These observations suggest that Rab GDI is essentially important for vesicle trafficking in neural cells, and its function may be needed to suppress hyperexcitability, likely through Rab3 proteins, because diovan weight.
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Group net sales rise 14% + 11% lc ; to USD 19.9 billion Dynamic performances from Sandoz and Vaccines and Diagnostics as well as solid growth in Pharmaceuticals and Consumer Health supported the double-digit expansion. Higher sales volumes represented seven percentage points of growth and acquisitions three percentage points, while currency translation had a positive impact of three points and net price changes added one point. Pharmaceuticals net sales advance 12% + 9% lc ; to USD 12.0 billion Ongoing strong growth in the top-selling brands Riovan USD 2.4 billion, + 19% lc ; and Gleevec Glivec USD 1.4 billion, + 14% lc ; both No. 1 in their segments underpinned the performance. Recently launched brands such as Exforge, Exjade, Lucentis, Prexige and Tekturna Rasilez continued growing rapidly. US net sales rose 5%, as growth in several brands helped offset the impact of the Zelnorm suspension in March and generic competition for Lotrel starting in May. Vaccines and Diagnostics net sales of USD 482 million Key drivers were growth in deliveries of components for use in combination pediatric vaccines as well as vaccines for tick-borne encephalitis. Diagnostics products, mainly used for blood testing, delivered further double-digit growth. The year-ago period included net sales for only two months following the April 2006 acquisition. Net sales on a comparable basis were up 45% over the 2006 period recorded by Chiron. Sandoz net sales expand 19% + 13% lc ; to USD 3.4 billion Recent US product launches, in particular for difficult-to-make products, underpinned the dynamic performance as this region accounted for 28% of total net sales. Improving positions in markets such as Eastern Europe, Scandinavia, Canada and Latin America further supported double-digit growth. Consumer Health continuing operations net sales up 9% + 6% lc ; USD 2.6 billion OTC provided strong growth ahead of the market thanks to strategic brands and expansion in emerging markets, while Animal Health benefited from further expansion in key markets.
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Welfare Reauthorization Table of Contents Interim Charge 2 2.1 Welfare Reform . 2.1 Background . 2.1 Eligibility . 2.2 Texas Eligibility Workers . 2.3 TIERS Implementation . 2.4 Work Requirements . 2.4 TANF Funding . 2.6 Funding in Texas . 2.7 Federal Welfare Reauthorization Activities . 2.9 Work-Related Requirements . 2.9 Supporting Working Families . 2.10 Marriage and Child Support Provisions . 2.11 Additional Reauthorization Provisions . 2.11 Barriers to Self Sufficiency . 2.12 Hardest to Serve . 2.12 Housing . 2.13 Sanctions . 2.13 Job Retention and Employment Advancement . 2.14 Immigrants . 2.15 Conclusion . 2.16 Recommendations . 2.17 Child Care . Background . Texas Child Care System . Funding for Child Care . Eligibility Criteria . Child Care Access . Quality Child Care . Child Care Reauthorization . Conclusion . Recommendations . Food Stamps . Background . Food Stamp Caseloads . Current Caseload Increases . Food Stamp Reauthorization . Mandated Changes to the Food Stamp Program . Partial Restoration of Benefits to Immigrants . Restructured Standard Deduction . 2.28 2.29 States can use TANF funds to operate programs that are designed to meet any one of the four purposes mandated by federal law, as follows: provide assistance to needy families so that children may be cared for in their own homes or in the homes of relatives; end the dependence of needy parents on government benefits by promoting job preparation, work, and marriage; prevent and reduce the incidence of out-of-wedlock pregnancies and establish annual numerical goals for preventing and reducing the incidence of these pregnancies; and 2.1 and gemfibrozil and diovan, for instance, generic name for diovan.
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14. Availability of pharmacopoeial standards The individual components that comprise the d4T 3TC NVP fixed-dose combination tablet are listed in the European and the US Pharmacopoeias; however the fixed dose combination tablet is not listed in either. The individual drugs have recently been included in the International Pharmacopoeia details are at : who.int medicines areas quality safety safety efficacy mon arvs en i ndex however, searches have not uncovered a monograph for the FDC either here or elsewhere. 15. Proposed text for the WHO Model Formulary The proposed text for the WHO Model Formulary is provided in Attachment 1.
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Dean Health Plan Formulary cont' Therapeutic Interchange List Note: Suggested interchange is product appropriate for MOST indications. Last Updated * 10 24 2006 Non-Preferred Not Covered Alternative * simvastatin ZOCOR SKELAXIN carisoprodol cyclobenzaprine methocarbamol Plan Exclusion SOLAQUIN-FORTE SOMA CMPD WITH CODEINE separate Rx's for individual drugs SONATA temazepam trazodone cefuroxime SPECTRACEF CEFZIL OMNICEF STARLIX glipizide glyburide STATACIN 1.5% erythromycin gel STRATTERA CONCERTA methylphenidate mixed amphetamine salts RITALIN LA SULAR nifedipine ER NORVASC SUPRAX cefuroxime CEFZIL OMNICEF SURE ONE INSULIN SYRINGE PRECISION BRAND SURMONTIL TAB amitriptyline doxepin imipramine SYMLIN LANTUS NOVOLIN NOVOLOG SYPRINE CUPRAMINE TACLONEX OINT Dovonex 0.005% and betamethasone dipropionate 0.05% TALACEN analgesic + acetaminophen TALWIN COMPOUND analgesic + aspirin TALWIN NX other analgesic TANAFED DM OTC Alternatives TARKA LOTREL TASMAR COMTAN TAZORAC tretinoin PA 35 or older ; TECZEM LOTREL TEGRETOL-XR CARBATROL TEMOVATE E clobetasol TERUMO INSULIN SYRINGE PRECISION BRAND TESTIM GEL ANDROGEL TESTODERM ANDROGEL TEVETEN DIOVAN THORAZINE SPANSULE chlorpromazine TIAMATE diltiazem TINDAMAX metronidazole.
It is not recommended to prescribe the maximum dose of 320 mg without prior up-titration. DIOVAN should be administered consistently with or without food See ACTION AND CLINICAL PHARMACOLOGY - Pharmacokinetics ; . Following Myocardial Infarction DIOVAN may be initiated as early as 12 hours after a myocardial infarction in clinically stable patients. In order to diminish the risk of hypotension, the recommended starting dose is 20 mg twice daily. Thereafter, patients may be uptitrated within 7 days to 40 mg twice daily, with subsequent titrations to a target maintenance dose of 160 mg twice daily, as tolerated. If symptomatic hypotension or renal dysfunction occurs, consideration should be given to dosage reduction. DIOVAN should be given with other standard post-myocardial infarction treatment, including thrombolytics, aspirin and statins, as indicated. Concomitant use of beta-blockers is to be encouraged with DIOVAN in this clinical setting, if indicated, since further substantial relative risk reduction may be expected with such use over that of valsartan alone see PHARMACOLOGY - Following Myocardial Infarction and effexor.
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Recommendation 2: The error rate for each pharmacogenomic test must be determined for each platform that is used in the laboratory. This should be conducted by analyzing pooled DNA samples from a renewable well characterized resource such as Corriell cells. The limit of sensitivity must be at least 10% variant in a background of 90% wildtype.
CO-DIOVAN TOTELLE CYCLE TOTELLE CYCLE NCH MINT NCH FRUIT H NCH FRUIT H CHIROCAINE CHIROCAINE NUTRINEAL PD4 WITH 1.1% AMINO ACIDS OLICLINOMEL N8-800 CELIPROLOL HYDROCHLORIDE CELIPROLOL HYDROCHLORIDE CEFOTAXIME SODIUM CEFOTAXINE SODIUM CEFOTAXIME SODIUM CEFTRIAXONE SODIUM CEFTRIAXONE SODIUM FLUCLOXACILLIN SODIUM FLUCLOXACILLIN SODIUM FLUCLOXACILLIN SODIUM VARIVAX VAMINOVEN 18 VAMINOVEN 18 EF STRUCTOKABIVEN STRUCTOKABIVEN ELECTOLYTE FREE BENPH BENPH BENPH BENPH SELIPROL.
Antidementia Drugs ARICEPT EXELON Antivirals NOTE: All brand oral antiviral ACE Inhibitors + HCT Antidepressants drugs for the treatment of bupropion, sr Combos HIV infection are formulary, benazepril, hctz CYMBALTA [SNRI] [ST] unless available generically. captopril, hctz mirtazapine, soltab acyclovir enalapril, hctz trazodone hcl amantadine fosinopril, hctz venlafaxine rimantadine lisinopril, hctz Antipsychotic Drugs TAMIFLU quinapril ABILIFY excluding Discmelt quinaretic & solution ; Cephalosporins haloperidol cefadroxil Angiotensin II Receptor cefpodoxime Antagonists + HCT Combos perphenazine BENICAR [ST] RISPERDAL cefprozil DIOVAN [ST] excluding M-tabs ; cefuroxime SEROQUEL cephalexin Beta-Adrenergic thioridazine hcl Antagonists Macrolides thiothixene azithromycin atenolol, -chlorthalidone trifluoperazine hcl clarithromycin bisoprolol fumarate hctz ZYPREXA excluding Zydis ; COREG * Oral Antifungals Antivertigo & Antiemetics INNOPRAN XL clotrimazole troche meclizine hcl labetalol hcl fluconazole prochlorperazine metoprolol, hctz itraconazole trimethobenzamide propranolol hcl, w hctz ketoconazole ZOFRAN, ODT * TOPROL XL * nystatin Calcium Antagonists Class II Narcotics Penicillins diltiazem, extended release fentanyl citrate amox tr potassium morphine sulfate felodipine er clavulanate oxycodone w acetaminophen nifedipine er amoxicillin OXYCONTIN SULAR [ST] penicillin v potassium verapamil hcl Class III Narcotics Quinolones Centrally Acting acetaminophen w codeine AVELOX Antihypertensives hydrocodone acetaminophen ciprofloxacin clonidine hcl ofloxacin CNS Stimulants HMG-CoA Reductase ADDERALL XR * Topical Antifungals Inhibitors dextroamphetamine sulfate ciclopirox METADATE CD * CRESTOR [ST] ketoconazole methylphenidate hcl lovastatin nystatin pravastatin Other Drugs For ADHD Topical Antifungalsimvastatin STRATTERA [ST] Corticosteroids clotrimazole betamethasone HMG-CoA Combinations Drugs To Prevent & Treat VYTORIN [ST] nystatin w triamcinolone Headaches Hypolipoproteinemics butalbital apap caffeine Urinary Antiinfectives IMITREX * nitrofurantoin macrocrystal cholestyramine ZOMIG, ZMT colestipol trimethoprim gemfibrozil Sedative Hypnotics OMACOR ANTINEOPLASTIC chloral hydrate NIASPAN IMMUNOSUPPRESSANT SONATA TRIGLIDE DRUGS temazepam ZETIA Selective Serotonin NOTE: All brand oral Thiazide & Related Drugs Reuptake Inhibitors hydrochlorothiazide antineoplastics are citalopram considered formulary, unless metolazone fluoxetine hcl available generically. fluvoxamine maleate azathioprine AUTONOMIC & CNS paroxetine CELLCEPT MEDICATIONS sertraline cyclosporine, modified Tertiary Amines HUMIRA [INJ] Anticonvulsants amitriptyline hydroxyurea carbamazepine doxepin hcl leucovorin DEPAKOTE imipramine megestrol gabapentin mercaptopurine lamotrigine methotrexate phenytoin sodium, extended tamoxifen TEGRETOL XR thioguanine TOPAMAX ANTIINFECTIVES CARDIOVASCULAR MEDICATIONS.
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Synaptic Responses Evoked by Paired-pulse Stimulation of the Hippocampus In most tested cells n 67 71, 94% ; , for increasing interstimulus inter vals ISI ; from 40 to 800 ms, paired-pulse stimulation PP ; induced a depression and or a facilitation of the early EPSP. Based on the variation in the amplitude of the early EPSP, three types of cells were distinguished: the PP-D cells n 37, 52% ; presented a depression Fig. 5 ; , the PP-DF cells n 20, 28% ; displayed a depression at short ISIs and a facilitation at longer ISIs Fig. 6 ; and finally the PP-F cells n 10, 14% ; showed a facilitation Fig. 7 ; . There was no apparent correlation between the type of cell PP-D, PP-DF and PP-F cells ; and the main electrophysiological classes of pyramidal cells RS, IB, NIB; Table 1 ; . The other components of the synaptic response were modified in some cases, as described below. PP-D Cells In the 37 PP-D cells, the early EPSP showed a maximal depression at ISIs of 4080 ms and recovered at ISIs ranging from 100 to 400 ms. A complete suppression of the early EPSP was observed in 16 cells, and in the other 21 cells the maximal decrease in the amplitude of the early EPSP was of 68 30% range, 18149%, P 0.001 ; . In the example of the PP-D cell shown in Figure 5A, the maximal decrease of the EPSP amplitude occurred at an ISI of.
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To The Editor: Although steroids for severe sepsis have a long and controversial history, many practicing intensivists are considering steroids based on several studies1, 2 suggesting efficacy in a defined group of patients with severe sepsis. In the largest trial to date, 3 although steroids were useful in a limited population with relative adrenal insufficiency and refractory septic shock, mortality increased 8% in those with normal adrenal function, and 50% of steroid recipients were dead at day 28. In a recent review by Marik et al June 2002 ; , 4 a therapeutic approach to patients with presumed adrenal insufficiency, or for that matter lack of adrenal reserve, is recommended in patients with severe sepsis. However, the fundamental issues remain of how to define relative adrenal insufficiency in critically ill patients. More studies are needed to identify the prevalence of relative adrenal insufficiency, which will be dependent on the diagnostic criteria used to confirm this syndrome in critically ill patients. Additionally, we need to better define the precise dose and composition of steroids and the potential interaction of steroids and other proven interventions that have been shown to enhance severe sepsis outcome. Though many intensivists are "jumping on the steroid bandwagon, " we must remain cautious in our haste to accept the benefits of steroids without careful considerations of its effects, especially in patients who do not have adrenal insufficiency. There has been growing optimism in the field of critical care medicine owing to our better understanding of the pathophysiology underlying severe sepsis. We now recognize that hemostatic abnormalities appear to be almost universal in patients with severe sepsis, with the coagulation and fibrinolytic systems being profoundly deregulated during sepsis. Drotrecogin alfa activated ; has clearly demonstrated outcome benefit in patients with severe sepsis, perhaps attributed to its multiple mechanisms of action, including modulation of the inflammatory responses, and displaying both antithrombotic and profibrinolytic properties.5 Threatening bleeds and intracranial hemorrhage appear to be uncommon in approximately 2, 786 treated patients in controlled and open-label trials 0.4% and 0.5%, respectively ; . The reduction in mortality with this drug is far greater than the risk of a.
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Serum potassium 3.5 mEq L ; was 4.5%; the incidence of hyperkalemia serum potassium 5.7 mEq L ; was 0.3%. Two patients 0.3% ; discontinued from a trial for decreases in serum potassium. In controlled clinical trials of Diiovan HCT valsartan and hydrochlorothiazide, USP ; , the average change in serum potassium was near zero in subjects who received D9ovan HCT 160 12.5 mg, but the average subject who received Diovan HCT 80 12.5 mg, 80 25 mg or 160 25 mg experienced a mild reduction in serum potassium. In clinical trials, the opposite effects of valsartan 80 or 160 mg ; and hydrochlorothiazide 12.5 mg ; on serum potassium approximately balanced each other in many patients. In other patients, one or the other effect may be dominant. Periodic determinations of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.
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