This report describes, for the first time, the isolation of anaerobic bacteria from children with diskitis. The lack of their recovery in previous reports and the absence of bacterial growth in over two thirds of these studies25, 10 12 may be attributable to the use of improper methods for their collection, transportation, and cultivation. Proper choice of antimicrobial therapy for diskitis can be accomplished only by identification of the causative organisms and of its antimicrobial susceptibility. This is of particular importance in infections caused by anaerobic bacteria that are often resistant to antimicrobials used to empirically treat diskitis.
That I have been responsible for many of the ongoing organizational tasks for CfM, and not always able to do them as well or in as timely a manner as they should be done. At the same time, the work of CfM has broadened, with new opportunities to bring the "consumer voice" into national discussions and initiatives about maternity care. Like you I have a family, I also have a part time job, and my age is creeping up on me with minor but important health concerns, all of which require time and attention. Therefore, during the past year the newsletter in particular has become a difficult burden for me. I, along with the rest of the Board, have concluded that it is time for me to step down from the newsletter. I will no longer be conjuring up and editing the CfM News. We are eagerly looking for one or more people to assume responsibility for coordinating the newsletter. In addition, the Board is in the process of exploring new possibilities for the CfM News, such as an e-news format or a webbased newsletter. If the opportunity to work with the Board, be creative, and take the CfM News to a new level interests you, please email us about your experience and interest at newsletter cfmidwifery . As you will read in the various reports in this issue, the Board members slowly but surely are working on ways to improve CfM so we can accomplish more with less work, as well as make it easier for volunteers to take on well-defined tasks. However, these improvements take time. And during the past year or two our Board members have experienced our share of life experiences life and death, children growing up, surgery, new jobs, etc. Our motto is "family first" which means sometimes CfM work has to wait. All things considered, we continue to accomplish an amazing amount, and past accomplishments remain useful on the CfM website, for example, domperidone for gastroparesis.
From the aDivision of Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, bDivision of Cardiology, University of North Carolina, Chapel Hill, Chapel Hill, NC, cThe Cleveland Clinic Foundation, Cleveland, Ohio, d Pennsylvania Hospital, Philadelphia, Pa, and eUniversity of Cincinnati School of Medicine, Cincinnati, Ohio. CRUSADE is funded by Millennium Pharmaceuticals, Inc., and Schering Corporation. Bristol-Myers Squibb Sanofi Pharmaceuticals Partnership provides an unrestricted grant in support of the program. Submitted November 30, 2004; accepted February 9, 2005. Reprint requests: Trip J. Meine MD, PO Box 17969, Duke Clinical Research Institute, Durham, NC, 27705. E-mail: meine001 mc.duke 0002-8703 $ - see front matter n 2005, Elsevier Inc. All rights reserved. doi: 10.1016 j.ahj.2005.02.010.
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Index Diarrhea, and acute otitis media, 9 -3 AIDS, 18-2 botulism, 18-3 bowel obstruction, 12-14 dehydration, 4-1 gastroenteritis, 12-3 intussusception, 12-16 iron poisoning, 20-14 lactose intolerance, 17-11 milk protein sensitivity, 17-10 roseola infantum, 18-11 urinary tract infection, 13-3 See also Gastroenteritis Diazepam and breast milk toxicology, 7-6 for seizures, 15-6 Diet. See Nutrition and diet Digoxin and breast milk toxicology, 7-6 for cardiac failure, 11-8 Diphenhydramine hydrochloride, uses anaphylaxis, 20-9 chickenpox, 18-13 hives urticaria ; , 17-9 poison ivy dermatitis, 16-10 pruritus, 16-5 Diphtheria, 18-13 to 18-15 and bacterial pharyngotonsillitis, 9-8 cause and transmission, 18-13 to 18-14 history and physical findings, 18-14 to 18-15 management, 18-14 to 18-15 vaccines, 18-14 Dislocation of hip, congenital hip dysplasia ; , 14-5 to 14-6 Dislocations, major joints, 14 -10, 14-13 to 14-14 Displaced fractures. See Fractures Diuretics, use in head trauma, 15-9 Domperidone, for GERD, 12 -10 Down's syndrome, weight height correlation, 3-5 DPT diphtheria-pertussis -tetanus ; vaccine, 18-14, 18-17 Drowning, safety precautions, 3-2 to 3-3 Drug abuse, 19-6 to 19-7 Dysfunctional problems, 6-1 to 6-5 attention deficit hyperactivity disorder, 6-4 to 6-5 fetal alcohol syndrome effects, 6-2 to 6-4 learning disabilities, 6-1 Dysphagia, and abscesses, retropharyngeal peritonsillar, 9-11 anaphylaxis, 20-8 botulism, 18-3 croup, 10-4 epiglottitis, 10-16 GERD, 12-9.
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One of the many neuropeptide receptors in the C. elegans genome, can also stimulate egglaying Schinkmann and Li, 1992; Waggoner et al., 2000 ; . In contrast, ser7 tm1325 ser-1 ok345 ; double mutants exhibited a modest, but statistically significant Egl-phenotype, suggesting that both 5-HT receptors may couple to at least some common downstream target s ; Table 3 ; . Interestingly, as observed above for pumping, 5-HT also appeared to dramatically inhibit normal egg-laying on bacteria in ser-7 null mutants Fig. 7 ; . In contrast, 5-HT did not inhibit egg-laying on bacteria in ser-7 tm1325 ser4 ok512 ; double mutants and actually stimulated egg-laying in these animals when applied alone Fig. 7 ; . As discussed more fully below, we hypothesize that SER-4 may function presynaptically to inhibit the release of neurotransmitters involved in the stimulation of egg-laying. Finally, ser-4 ok512 ; mutants appeared to retain fewer eggs than wild type animals, and also appeared to be slightly hyperactive for egg-laying in the presence of 5-HT Table 3; Fig. 7.
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Prokinetics Metoclopramide was the first prokinetic to be developed in the 1960s, from a programme that was evaluating local anaesthetics.47 It is structurally related to procainamide but has negligible local anaesthetic and cardiac effects, while having clinically significant effects on gastrointestinal motility.47 Metoclopramide has antidopaminergic activity and increases motility by enhancing the release of acetylcholine from postganglionic nerve endings of the myenteric plexus of gastrointestinal smooth muscle.48 This leads to an increase in lower oesophageal sphincter pressure, improved gastric peristalsis, enhanced pyloric activity and accelerated transit through the jejunum.49 There is no demonstrable effect on colonic motility.50 Metoclopramide reduces nausea and vomiting, and is more effective than placebo in healing oesophagitis.51 The drug is cheap and is generally well tolerated; however, it does cross the bloodbrain barrier and extrapyramidal side-effects occasionally occur, particularly when large doses are given to elderly subjects.52 Domperidome has a similar efficacy to metoclopramide53 but, as it does not cross the blood brain barrier, there is a much lower propensity to cause extrapyramidal side-effects.54 It is more expensive than metoclopramide but is still relatively cheap compared with other dyspepsia drugs.
TABLE 2. Guidelines for selection of patients for treatment of latent tuberculosis infection, by Mantoux PPD ; test result and propulsid, for example, domperidone babies.
The protein bands separated by SDS-PAGE were visualized by zinc staining Bio Rad Laboratories ; . The bands of interest were excised, subjected to in-gel digestion with trypsin, and the resulting peptide mixtures extracted as described 7 ; . Peptide mixtures were analyzed with MALDI-TOF MS using a delayed ion extraction and ion mirror reflector mass spectrometer VoyagerDE STR; Perseptive Biosystems ; . The measured masses of the tryptic peptides tryptic peptide map ; were used to search for protein candidates in the nonredundant protein sequence database with the program ProFound ProteoMetrics, New York, NY ; 8 ; . To confirm the protein identification results obtained from tryptic peptide mapping, peptide mixtures were analyzed by tandem MS fragmentation analyses using HPLC-ion trap mass spectrometry LCQ, Finnigan MAT, San Jose, CA ; equipped with a capillary HPLC Magic 2002, Michrom BioResources, Auburn, CA ; 9 ; and the protein search algorithm PepFrag ProteoMetrics ; 8.
On December 1, 2004, Council approved the following amendment to the Drug Schedules of the College's administrative bylaws, to become effective when levonorgestrel 0.75 mg per oral dosage unit is exempted from Schedule F to the Food and Drug Regulations. Until that time all products containing levonorgestrel 0.75 mg per oral dosage unit will remain a prescription only product as it is currently. Health Canada has published notice to de-regulate this drug for emergency contraception from prescription to non-prescription status. The National Drug Scheduling Advisory Committee has recommended Schedule II Status. As a result, Schedule I is amended, and Levonorgestrel, when sold in concentration of 0.75 mg per oral dosage unit is Schedule II once it has been de-regulated by Health Canada. We will inform all members once this has occurred. Schedule II status means Non-Prescription, No Public Access. The pharmacist must be involved in each sale. However, this is not the only standard that must be met. Once levonorgestrel has been de-regulated to Schedule II status, pharmacists in Saskatchewan must continue to follow the same standards and guidelines as are currently in place for the sale of Emergency Post-Coital Contraception products. Because only properly trained licensed pharmacists may prescribe emergency contraception, only those pharmacists may sell levonorgestrel when it is deregulated to non-prescription status. Proper training means successful completion of programs accredited for at least 3.0 CEUs that aim to ensure the competency of pharmacists to prescribe emergency contraception. Please refer to the following documents in the Pharmacy Reference Manual: Emergency Post-Coital Contraception Standards and Guidelines for Pharmacists Prescribing Emergency Contraception Informed Consent Emergency Contraception How to Use Emergency Contraceptive Pills Information for the Patient Release of Confidential Records of Minors to Parents Guardians Moral Objection Statement Regarding Pharmacists' Refusal to Provide Products or Services for Moral or Religious Reasons Again, we will inform members when the de-regulation of levonorgestrel 0.75 mg per oral dosage unit is exempted from Schedule F to the Food and Drug Regulations and clemastine.
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The World Health Organization defines palliative care as the "active, total care of patients whose disease no longer responds to curative treatment. It ; affirms life and regards dying as a normal process.neither hastens nor postpones death. and ; provides relief from pain and other distressing symptoms."2 While the precepts of palliative care are rooted in the hospice movement, its delivery need not be limited to patients who are expected to die within six months, as originally conceived by Medicare. Nor should it be offered only to patients enrolled in hospice and clopidogrel.
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478 hypotension, hypertensive crisis especially in patients with pheochromocytoma, arrhythmias, drowsiness, interference with absorption of orally administered drugs, and extrapyramidal symptoms. 914 " 20 In conclusion, our present study demonstrated that metoclopramide has a significant inhibitory effect on PCHE activity when tested in vitro. Our data also show that the concentration of metoclopramide required to inhibit 50 per cent of PCHE activity I50 ; was 0.8 ig-ml"'. We recommend that neuromuscular paralysis be monitored with a peripheral nerve stimulator in patients receiving metoclopramide and succinylcholine. In addition, we suggest the combination of metoclopramide and ester type of local anaesthetics be avoided in pregnant patients and others, who already have diminished PCHE activity. References 1 Cooke RD, Comyn DJ, Ball BW. Prevention of postoperative nausea and vomiting by domperidone. A double blind randomized study using domperidone, metoclopramide and a placebo. South African Med J 1979; 56: 827-9. PajewskiM, EshcharJ, ManorA. Visualization of the small intestine by double contrast. Clinical Radiol 1975; 26; 491-3. Harrington RA, Hamilton CW, BrogdenRN, Linkewich. JA, RomankiewiczJA, HeelRC. Metoclopramide, an up-date review of its pharmacological properties and clinical use. Drugs 1983; 25: 454-71. Kambam JR, Naukam RJ, Sastry BVR. The effect of procainamide on plasma cholinesterase activity. Can J Anaesth 1987; 34: 579-81. ZapfPW.CoghlanCHM. A kinetic method for the estimation of pseudocholinesterase using naphthyl acetate substrate. Clin Chim Acta 1974; 43: 237-42. Erdos EG, Baart N, Shanor SP, Foldes FF. The inhibitor effect of chlorpromazine and chlorpromazine sulfoxide on human cholinesterases, Arc Int Pharmacodyn Trier 1958; 117: 163-8. Harrington RA, Hamilton CW, Brogden RN, Linkewich JA, Romankiewicz JA, Heel RC. Metoclopramide, an up-date review of its pharmacological properties and clinical use. Drugs 1983; 25: 470-1. Batemn DN, Kahn C, Davies DS. Concentration effect studies with oral metoclopramide. Br J Clin Pharmacol 1979; 8: 179-82. Gralla RJ, Itri LM, Pisko SE, Squillante AE, Kelsen DP. Antiemetic efficacy of high dose metoclopramide: Randomized trials with placebo and prochlorperazine in patients with chemotherapy induced nausea and vomiting. N Engl J Med 1981; 305: 905-49. Stanley M, Lautin A, RotrosenJ, GershonS, Kleinberg.
Administration of the dopamine antagonist domperidone at a dose of 1.1 mg kg or 2.2 mg kg body weight PO q 24 did not significantly advance the day of the first ovulation of the year in deep anestrous mares maintained outside under ambient light conditions or in transitional mares maintained inside under a stimulatory artificial photoperiod. Authors' addresses: Animal Reproduction and Biotechnology Laboratory, Colorado State University, Ft. Collins, CO 80523 McCue, Buchanan, Farquhar, and Squires ; Animal, Dairy and Veterinary Sciences Department, Clemson University, Clemson SC 29634 Cross ; . 1999 AAEP and cromolyn.
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Neither of these procedures is without complications such as perforation, bleeding, pleural and pericardial effusion, pneumonia, severe chest pain, permanent dysphagia and death. The most frequent complication is chest pain, which after the Enteryx procedure occurred in more than 80 % of treated patients. Complaints were usually transitional, but very often prolonged ones. So far, only patients with mild or moderate symptoms of GORD have been enrolled into groups treated by the above mentioned methods 8 ; . The developing endoscopic treatment appears to be an alternative to surgical and pharmacological management. Patients eligible for the endoscopic therapy are those with clearly determined diagnosis of GORD, with abnormal pH values, with normal oesophageal motility who at least partially respond to PPI. The presence of hiatal is not a hindrance for laparoscopic fundoplication, however, if endoscopy is considered, hiatal hernia should not be longer than 3 cm 9 ; Endoscopic management is not for the time being recommended for the treatment of patients with erosive disease and with a large hiatal hernia 28 ; . It questionable if trials of the endoscopic methods are going to continue in all studies conducted so far GORD symptoms have improved, however, no significant reduction of gastro-oesophageal reflux has been observed, neither has the pressure of the lower oesophageal sphincter increased 5, 14, 24 ; . The future Oesophageal and gastric disorders of motility are key factors in the pathogenesis of GORD. They include the incompetence of the lower oesophageal sphincter, insufficient oesophageal clearance and delayed gastric emptying. In case these factors are controlled, gastric acid suppression would not be mandatory. Several drugs belonging to this group sometimes they are called pro-motility drugs this name may be better than pro-kinetics ; elicit side effects such as sleepiness, excitation, extrapyramidal effects, these are observed with metoclopramide and betanechol. Domperidone, a dopamine receptors blocker, which does not penetrate the haematoencephalic barrier, shows hyperprolactinaemia as a side effect. Tegaserode is a 5HT3 agonist with promotility and anti-nociceptive effects. It improves the acid exposure in the oesophagus but it has not been 22 and
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Table 1. Effects of Drugs on Agrin-induced AChR Aggregation and desmopressin.
National and international epidemiological studies on the possible role of antihistamines in relation to traffic accidents are relatively scarce, and their results are moreover difficult to interpret. 1. Descriptive cross-sectional studies [15]. These have been carried out among drivers. The most salient observation in studies of this kind is the fact that selfmedication and the simultaneous consumption of alcohol is common practice. Seventeen percent of the drivers are found to consume medication on a habitual basis, and up to 5% regularly use drugs known to alter the ability to drive. In turn, 63% admit consuming alcohol at least once a week.
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E0616 S2202 S2220 S2205 Implantable cardiac event recorder with memory, activator, and programmer Echosclerotherapy Thrombectomy, coronary, by mechanical means e.g., using rheolytic catheter ; Minimally invasive direct coronary artery bypass surgery involving mini-thoracotomy or ministernotomy surgery, performed under direct vision; using arterial graft s ; , single coronary arterial graft Minimally invasive direct coronary artery bypass surgery involving mini-thoracotomy or ministernotomy surgery, performed under direct vision; using arterial graft s ; , two coronary arterial graft Minimally invasive direct coronary artery bypass surgery involving mini-thoracotomy or ministernotomy surgery, performed under direct vision; using venous graft only, single coronary venous graft Minimally invasive direct coronary artery bypass surgery involving mini-thoracotomy or ministernotomy surgery, performed under direct vision; using single arterial and venous graft s ; , single venous graft Minimally invasive direct coronary artery bypass surgery involving mini-thoracotomy or ministernotomy surgery, performed under direct vision; using two arterial grafts and single venous graft Simultaneous pancreas kidney transplantation Yes Yes Deleted Yes Effective 01 Deleted 12 31 01 and cisapride.
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Prostate cancer is a major health concern for Western patients who are facing important decisions, alongside with the physicians, concerning their treatment. Additionally, the physician has to take into account the potential side effects of the disease and the treatment itself. Treatment for advanced prostate cancer produces problematic physical and psychosocial side effects. The patient should be asked by the physician for information concerning daily life activities, overall satisfaction voiding ability, and sexual activity in a standardized questionnaire assessing the quality of life QoL ; of the patient. Many such questionnaires and studies have been evaluated or are still in progress. Modern QoL questionnaires are considered to be more than a necessity nowadays for the improvement of the treatment administered from the physician and the performance and functional status of the patient. Key Words: quality of life QoL ; , advanced prostate cancer, for example, omeprazole and domperidone.
PARKINSON'S DISEASE -- The involvement of the GI tract may also cause symptoms in other regions including, frequently, the stomach. 20 Delayed gastric emptying may result in early satiety, poor nutritional intake, and weight loss. The individual often describes sitting down to a meal with a good appetite but experiencing an uncomfortable sensation of fullness after only a few bites. Reflux disease is often another consequence of this slowness of gut transit time. Nausea may also be due to medications. When levodopa is converted to dopamine in the bloodstream, nausea is a frequent complaint. The addition of carbidopa to levodopa prevents this from occurring in most persons. Some, however, require additional carbidopa to block conversion. This can be ordered in the form of Lodosyn , which contains only carbidopa. 21 Other medications, such as domperidone and ondansetron, can also treat nausea in these patients when additional carbidopa is not effective, though domperidone is not available in the United States. 21 TEMPERATURE CONTROL Patients often complain of discomfort involving temperature regulation. As with so many other nonmotor symptoms, alterations in temperature perception may occur as a result of autonomic dysfunction.3 Many patients also experience a sensation of being overheated and diaphoretic as a symptom of wearing-off of dopaminergic medication effect. This frequently occurs during the night, when medication levels are at their lowest, and can usually be treated by adjusting the medications to last through the night using controlledrelease carbidopa levodopa or a long-acting dopamine agonist at bedtime. PAIN Although PD is generally conceptualized as a motor disorder, pain is actually a frequent complaint. The patient often describes aching in limbs, often the shoulder, which may be due to the stiffness and rigidity that are part of PD and, as such, may be relieved by antiparkinsonian medications.3 Pain may also come, as changes in posture aggravate degenerative conditions, such as spinal stenosis or cervical and lumbar radiculopathies. ANOSMIA It has become increasingly recognized that people with PD commonly lose the sense of smell. In fact, Lewy bodies have been found in the olfactory neurons. 6 It has been suggested that PD may actually have its origin in these neurons or in those of the enteric nervous system.8 ORTHOSTATIC HYPOTENSION Orthostatic hypotension often occurs in PD because of the involvement of the autonomic nervous system, as well as antiparkinsonian medications. It may occur in up to 50% of patients and is more common in older patients taking large amounts of dopaminergic medication.22 In general, this is not a significant symptom until later in the disease. When blood pressure is measured sitting and standing, some degree of decline may be recorded, but the patient may not be symptomatic. When orthostatic hypotension is profound and occurs early in the disorder, this raises the possibility that the parkinsonism is due to multiple systems atrophy rather than idiopathic PD. Medications such as midodrine or fludrocortisone may be helpful, though they may cause dangerous elevations in supine blood pressure. Therefore, close monitoring of supine and standing blood pressures is warranted. Pyridostigmine has been successfully used to treat some patients with neurogenic orthostatic hypotension and may be less likely to cause supine hypertension.23 Other measures, such as attention to fluid and salt intake, sleeping with the head of the bed elevated, and eating multiple small meals to avoid diverting large amounts of blood to the GI tract, should also be implemented.
Pharmacies were the least likely to give lifestyle advice compared to the other formats 2 9.596; p 0.05.
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In the ATP-sensitive K + channel subunit of the Kir6.2 gene in 7 of patients with neonatal diabetes 86 ; . This gene plays a critical role in glucose-stimulated insulin secretion. Remarkably, several patients who previously required insulin injections were taken off insulin and treated with oral medication, which again illustrates the efficacy of pharmacogenetics for treatment of some diabetics. A large number of clinical trials for both T1D and T2D are currently being conducted. The Type 1 Diabetes Genetics Consortium T1DGC; : t1dgc ; will organize international efforts to identify genes that determine an individual's risk of T1D through the identification of 2, 500 new families with 2 or more affected siblings. To explore approaches to treatment of T2D in youth, the TODAY Treatment Options for Type 2 Diabetes in Adolescents and Youth; : TODAYstudy ; study will enroll 750 children and teenagers that have recently been diagnosed with T2D. Participants will be assigned to groups for treatment aimed at weight reduction and increasing physical activity. The Look AHEAD Action for Health in Diabetes ; trial is a multicenter, randomized clinical trial that will examine the consequences of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and increased exercise in 5, 000 obese patients with T2D. The National Heart, Lung, and Blood Instituteled Action to Control Cardiovascular Risk in Diabetes ACCORD ; trial is designed to test the effects of glycemia and blood pressure control on major CVD events and the use of fibrate treatment to increase HDL cholesterol and lower triglycerides : accordtrial public index ; . The Bypass Angioplasty Revascularization Investigation 2 Diabetes BARI 2D ; trial : bari2d ; addresses questions about therapy in adults with T2D and stable CAD who might be candidates for revascularization. These studies represent ideal opportunities to incorporate DNA diagnostic testing and assessment of variable responses to therapeutic interventions. Large prospective cohort study for the effects of genes and environment on diabetes While case-control studies have much to offer for the assessment of the interactions between genes and environmental factors, Francis Collins noted that clinically diagnosed cases may represent only the more severely affected individuals with the disease and highlighted the difficulties of selecting an unbiased control group 87 ; . To more accurately quantify genetic contribution and population-wide risk, he proposed prospective, population-based cohort studies 88 ; . In.
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Resistance exercise training on vascular function in heart failure. J Physiol 2000; 279: H1999 2005. Ivy JL. Role of exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus. Sports Med 1997; 24: 32136. Joannides R, Haefeli WE, Linder L, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 1995; 91: 1314 Green DJ, Fowler DT, O'Driscoll JG, Blanksby BA, Taylor RR. Endothelium-derived nitric oxide activity in forearm vessels of tennis players. J Appl Physiol 1996; 81: 943 Green DJ, O'Driscoll JG, Blanksby BA, Taylor RR. Effect of casting on forearm resistance vessels in young men. Med Sci Sports Exerc 1997; 29: 132531. Benjamin N, Calver A, Collier J, Vallance P, Webb D. Measuring forearm blood flow and interpreting the responses to drugs and mediators. Hypertension 1995; 25: 918 Green DJ, Cable NT, Fox C, Rankin JM, Taylor RR. Modification of forearm resistance vessels by exercise training in young men. J Appl Physiol 1994; 77: 1829 Koller A, Huang A, Sun D, Kaley G. Exercise training augments flow-dependent dilation in rat skeletal muscle arterioles. Circ Res 1995; 76: 544 Belardinelli R, Georgiou D, Cianci G, Purcaro A. Randomised, controlled trial of long-term moderate exercise training in chronic heart failure. Effects on functional capacity, quality of life, and clinical outcome. Circulation 1999; 99: 1173 Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension 1986; 8: 37 Rubanyi GM, Romero JC, Vanhoutte PM. Flow-induced release of endothelium-derived relaxing factor. J Physiol 1986; 250: H11459. Koller A, Sun D, Huang A, Kaley G. Co-release of nitric oxide and prostaglandins mediates flow-dependent dilation of rat gracilis muscle arterioles. J Physiol 1994; 267: H326 32. Friebel M, Klotz KF, Ley K, Gaehtgens P, Pries AR. Flow-dependent regulation of arteriolar diameter in rat skeletal muscle in situ: role of endothelium-derived relaxing factor and prostanoids. J Physiol 1995; 483: 71526. Quyyumi AA, Dakak N, Andrews NP, Gilligan DM, Panza JA, Cannon RO. Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation 1995; 92: 320 Gilligan DM, Panza JA, Kilcoyne CM, Waclawiw MA, Casino PR, Quyyumi AA. Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation 1994; 90: 2853 Dyke CK, Proctor DN, Deitz NM, Joyner MJ. Role of nitric oxide in.
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