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PANRETIN . papaverine . PARAPLATIN . PARNATE . paroxetine PATANOL . PEGANONE . PEGASYS . PEG-INTRON pemoline pergolide . permethrin . perphenazine . phenoxybenzamine . phentolamine . phenylephrine phytonadione . pilocarpine . 11, 15 pindolol . piperacillin . piroxicam . PLAN B PLAVIX . PODOCON - 25 polyethylene glycol 3350 NF potassium . potassium and sodium . potassium, monobasic . povidone-iodine pramoxine and hydrocortisone . PRANDIN. For 2003, the Company reported annual global sales of $20.9 billion. Sales increased 15% from the prior year level, reflecting volume increases of 9%, net price increases of 2% and a 4% impact from foreign exchange fluctuations. U.S. sales increased 14%, partly due to the impact on 2002 sales from the workdown of non-consignment wholesaler inventory, while international sales increased 18%, including a 10% favorable foreign exchange impact. In 2003, the Company had two product lines with sales of over $2.0 billion each-- Pravachol and Plavix. Pravachol sales grew 25%, including a 7% favorable foreign exchange impact, to $2.8 billion, and Plavjx sales grew 31%, including a 3% favorable foreign exchange impact, to $2.5 billion. In addition to these two products, the Company had 45 product lines with more than $50 million each in annual sales, including 29 product lines with more than $100 million each in annual sales, of which six had annual sales in excess of $500 million each. Earnings from continuing operations before minority interest and income taxes increased 70% to $4, 694 million in 2003 from $2, 761 million in 2002. Net earnings from continuing operations were $3, 106 million, or $1.60 and $1.59 per share on a basic and diluted basis, respectively, compared to $2, 067 million, or $1.07 and $1.06 per share on a basic and diluted basis, respectively, in 2002. While the Company expects exclusivity losses and new product mix to challenge its margins, the Company remains committed to investing in its businesses to maximize key growth drivers and to advance its pipeline. Several items affected the comparability of the results between 2003 and 2002, as discussed below under "Earnings" and "Outlook for 2004." At December 31, 2003, the Company held almost $5.5 billion in cash, cash equivalents and marketable securities. Approximately $5.4 billion of such cash, cash equivalents and marketable securities were held by the Company's foreign subsidiaries, which the Company does not expect to repatriate in the foreseeable future. In 2004, the Company expects cash generated by its U.S. operations, together with borrowings from the capital markets, to sufficiently cover cash needs for working capital, capital expenditures and dividends in the U.S. Repatriation to the United States would require additional tax provisions not reflected in the consolidated financial statements. For a further discussion of this matter, see "Critical Accounting Policies--Income Taxes" below. The Company and its subsidiaries are the subject of a number of significant pending lawsuits, claims, proceedings and investigations. It is not possible at this time reasonably to assess the final outcome of these investigations or litigations. Management continues to believe, as previously disclosed, that during the next few years, the aggregate impact, beyond current reserves, of these and other legal and procardia. Availability of we turn buy plavux place in reduced access threat. Statements on exclusivity are subject to any adverse determination that may occur with respect to the plaix * patent litigation and or the entry of generic competition earlier than expected.
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Kirsten Verkooijen * ; Gert A. Nielsen * ; Hans Chr. Petersen * * Department of Health Promotion Research, University of Southern Denmark; * Danish Cancer Society, Copenhagen; * Department of Statistics and Department of Health Promotion Research, University of Southern Denmark Introduction: Adolescence is a time when group behaviour is very apparent. It is also a period in which engagement in smoking tends to start off. The present study examined how group identification, perceived group behaviour and personal smoking behaviour are interlinked. Instrument: Data was gathered as part of a larger national survey on health and health behaviour among 16 to 20 year old Danes N 3956 ; carried out by the Danish Cancer Society and The Danish Board of Health in November 2002. Subgroup identification was assessed by the question: `would you agree if a friend called you a.[group name]'. Perceived group behaviour was assessed by the question: `How likely is a member of .[group name] to be a smoker?' Nine group names, based on prior group discussions with representatives of the target population, were provided. Answers were given on 5-point scales. Respondents were also asked about their personal smoking behaviour. Data-analysis: Risk ratios for smoking by group identification and by perceived group behaviour were calculated for each subgroup. Results: For all except one subgroup, identification with the group was related to either a significantly higher or a significantly lower risk of being a smoker. Within five subgroups, the relative risk of being a smoker was significantly higher for `identifiers' who perceived group members as smokers compared to `identifiers' who perceived group members not to be smokers. Conclusion: Group identity seems to play an important role in Danish adolescents' smoking behaviour with perceived group behaviour as a mediating factor Lusa Barros e Fernando Fradique Faculdade de Psicologia e de Cincias da Educao In the last decade, several studies have investigated health risk and protection behaviours in school-aged children. Most agree that the majority of children and adolescents have relatively healthy life-styles, but show that a small percentage of young people are at high risk for developing health problems in the short term alcohol consumption, unprotected sexual activity ; , or have health habits that jeopardise their future health smoking, poor eating habits ; . Some authors have defended that the adoption of unhealthy life-styles is related to others psychological risks or areas of disturbance in the child's developmental course. Others emphasise the importance of culture, structure and environment, and family variables. In this study we wanted to gain a better understanding of who are the young people who have more risk and less protection behaviours, how the several risk and protection behaviours associate, and what is the relationship between school failure and poor health habits. We studied about 2500 students 9-21 years ; attending schools in a suburban region nearby Lisbon, using the "Health Behaviours Questionnaire" from the European Health and Behaviour Survey portuguese adaptation, McIntyre , Soares e Silva, 1977 ; . In this poster we analyse the association between different risk behaviours and protection behaviors, and between these behaviours and other variables sex, age, parents education, school failure ; .The results are discussed in terms of some possible implications for health education in schools and plendil.
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The last exposure to grapefruit juice. As little as one glass of grapefruit juice 8 oz. or 250 mL ; can cause an effect and the effects can last for three days or more. Therefore, even if you drink the juice in the morning and do not take your medication until bedtime, the level of the drug in your blood could still be affected. The drugs affected by this include calcium channel blockers used for treatment of hypertension ; , antihistamines used in allergies ; , immunosuppressants used mainly after transplants ; , cholesterol-lowering drugs, certain antibiotics, HIV protease inhibitors and others. The reduced breakdown metabolism ; of these drugs results in increased concentrations of the drug in the blood, which can have clinical consequences. There are several substances in grapefruit that interfere with the way your body handles these drugs. Consuming grapefruit or its juice fresh or frozen ; can increase, or less commonly decrease, the effects of some drugs. Sour oranges, such as Seville oranges, or their juice, may have an effect similar to grapefruit juice. Most other citrus fruits, such as lemons, limes, citrons, naturally sweet oranges and tangerines are not thought to have this effect. However, tangellos, a hybrid of grapefruit, may also interfere with drugs. It should be noted that the interaction is not due to vitamin C or citric acid and so other citrus fruit do not exhibit the same effects as grapefruits. The effects vary from one person to another, from one drug to another, and from one grapefruit juice preparation to another. This results in an unpredictable increase in blood drug level, which in some cases can cause serious effects. As a practical means of prevention and since so many commonly prescribed medications are on the "forbidden fruit" list, it would be recommended that hospitals no longer have grapefruit juice and grapefruit on their menu. Also, physicians should be better informed about this issue and similarly, pharmacists should be diligent in affixing warning labels. MINIMIZING YOUR RISK Take the following precautions to minimize the risk of adverse effects when consuming grapefruit or its juice.
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9. Bertrand M E, Rupprecht H J, Urban P et al., "Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study CLASSICS ; ", Circulation 2000 102: pp. 624629. 10. Gurbel P A, Cummings C C, Bell C R et al., "Onset and extent of platelet inhibition by clopidogrel loading in patients undergoing elective coronary stenting: the Plavix Reduction Of New Thrombus Occurrence PRONTO ; trial", Heart J 2003 145: pp. 239247. 11. Schofer J, Schluter M, Gershlick A H et al., "Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomised controlled trial E-SIRIUS ; ", Lancet 2003 362: pp. 1, 0931, 099. Schampaert E, Cohen E A, Schluter M et al., "The Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries C-SIRIUS ; ", J Coll Cardiol 2004 43: pp. 1, 1101, 115. Lemos P A, Serruys P W, van Domburg R T et al., "Unrestricted utilization of sirolimus-eluting stents compared with conventional bare stent implantation in the "real world": the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital RESEARCH ; registry", Circulation 2004 109: pp. 190195. 14. Colombo A, Drzewiecki J, Banning A et al., "Randomized study to assess the effectiveness of slow- and moderate-release polymer-based paclitaxel-eluting stents for coronary artery lesions", Circulation 2003 108: pp. 788794. 15. Gershlick A, De Scheerder I, Chevalier B et al., "Inhibition of restenosis with a paclitaxel-eluting, polymer-free coronary stent: the European evaLUation of pacliTaxel Eluting Stent ELUTES ; trial", Circulation 2004 109: pp. 487493. 16. Nguyen T A, Diodati J G, Pharand C, "Resistance to clopidogrel: a review of the evidence", J Coll Cardiol 2005 45: pp. 1, 1571, 164. Gum P A, Kottke-Marchant K, Welsh P A, White J, Topol E J, "A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease", J Coll Cardiol 2003 41: pp. 961965. 18. Wenaweser P, Dorffler-Melly J, Imboden K et al., "Stent thrombosis is associated with an impaired response to antiplatelet therapy", J Coll Cardiol 2005 45: pp. 1, 7481, 752. Developing Clinical Practice Recommendations for Healthcare Professionals One place to start a diabetes care program within a healthcare setting, is to develop clinical practice recommendations. 47 Clinical practice recommendations for diabetes care are available from the American Diabetes Association and other professional organizations. However, in order to achieve acceptance and use of the guidelines it is often necessary to tailor clinical practice recommendations to each hospital or healthcare system. The process for local development is outlined in the following table. Guidelines require ongoing review and updating. This process can also be used as the starting point in a community-based or regional collaborative see Example--Diabetes Coalitions in New Mexico, Missouri, and New York ; . Guidelines Development Process 48 1. Put together your guidelines development team: Clinical champion Administrative leader Day-to-day leader Technical expert Community representative Patient advocate 2. Compile published guidelines 3. Supplement with recent reviews: Written after or not included in the published guidelines 4. Conduct a focused literature review 5. Customize the guidelines for your facility to promote ownership 6. Develop tools mechanisms to assist implementation: Standing orders, reminder systems, and system changes 7. Educate Providers: Academic detailing 8. Monitor implementation and adherence: Plan-Do-See-Act cycles 9. Fine tune guidelines continuously: Update from the medical literature Modify on the basis local use.

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